Organic Acid Test

The Organic Acid Test measures organic acids in the blood. These are byproducts of metabolism. It is ordered to check for rare metabolic disorders or to investigate unexplained symptoms.

What it measures

Methylmalonic acid — A marker for vitamin B12 deficiency.
Homovanillic acid — A breakdown product of dopamine, a brain chemical.
Vanillylmandelic acid — A breakdown product of adrenaline and noradrenaline.
Orotic acid — A marker for certain urea cycle disorders.
Pyroglutamic acid — Can indicate a metabolic imbalance.

Who it is for

It is typically ordered by metabolic specialists, neurologists, or pediatricians when a metabolic disorder is suspected.

Preparation

No special preparation is usually needed. Fasting may be required if other tests are done at the same time.

Results and what they mean

Results are reported as levels of each organic acid, often with a reference range. A clinician interprets them in the context of your health. This is general information, not medical advice.

How to order this test

Choose the test and place a confidential order online.
Select a certified collection site and pick a time that suits you.
Have your specimen collected — most draws take only a few minutes.
Review results in a secure portal, typically within 1–3 days.

Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.

Availability by state

Direct-access online ordering for the organic acid test is available in most states. It is currently unavailable in 6 states:

Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →

Frequently asked questions

Is this test painful?

It uses a blood sample, so you may feel a brief pinch.

How long do results take?

Typically 1-3 business days.

Can I eat before the test?

Usually yes, unless your clinician instructs otherwise.

Are results kept private?

Yes, your results are confidential and shared only with your care team.