Methadone Screen and Confirmation
Methadone Screen and Confirmation is a laboratory test you can order directly. A methadone screen and confirmation test checks for methadone, a prescription medication used to treat opioid dependence and pain, in a blood sample. It is ordered to monitor therapy, detect misuse, or investigate unexplained symptoms.
- Sample type
- blood
- Category
- Drug & Urine Screening
- Turnaround
- 1-3 business days
- Price
- $108
- Referral
- Not required
A methadone screen and confirmation test checks for methadone, a prescription medication used to treat opioid dependence and pain, in a blood sample. It is ordered to monitor therapy, detect misuse, or investigate unexplained symptoms.
What it measures
- Methadone — The primary drug being tested for.
- EDDP — A breakdown product of methadone that confirms recent use.
- Other opioids — Sometimes included to check for additional substances.
Who it is for
Healthcare providers order this test for patients in methadone treatment, those with suspected overdose, or in workplace or legal settings where drug testing is required.
Preparation
No fasting or special preparation is needed. Tell your provider about all medications you take, as some can affect results.
Results and what they mean
Results are reported as positive or negative, with a level if positive. A positive result means methadone or its breakdown product was found; negative means it was not. Only a qualified healthcare provider can interpret these results in your specific context. This information is not medical advice.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the methadone screen and confirmation is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
How long does methadone stay in my blood?
Methadone can be detected in blood for about 24 to 36 hours after the last dose, but this varies by person and dose.
Can other medications cause a false positive?
Some drugs, such as certain antidepressants or antihistamines, may interfere with screening tests, but confirmation testing is more specific.
Is this test confidential?
Yes, your test results are protected health information and are kept private under privacy laws.
What is the difference between a screen and a confirmation?
A screen is a quick initial test; a confirmation is a more precise follow-up that verifies the result.