Opiate Screen and Confirmation
This page explains the opiate screen and confirmation, what it measures, and how to arrange it. An opiate screen and confirmation is a two-step blood test that first checks for the presence of opiate-class drugs and then uses a more precise method to confirm any positive screen. It is ordered when a healthcare provider needs objective information about recent opiate exposure, such as in emergency care, pain-management monitoring, or pre-surgical evaluation.
- Sample type
- blood
- Category
- Drug & Urine Screening
- Turnaround
- 1-3 business days
- Price
- $49
- Referral
- Not required
An opiate screen and confirmation is a two-step blood test that first checks for the presence of opiate-class drugs and then uses a more precise method to confirm any positive screen. It is ordered when a healthcare provider needs objective information about recent opiate exposure, such as in emergency care, pain-management monitoring, or pre-surgical evaluation.
What it measures
- Opiate screen (immunoassay) — A rapid initial test that flags possible opiates in the blood.
- Confirmation (mass spectrometry) — A precise follow-up that identifies specific opiates and reduces false positives.
- Morphine — A common opiate that may be detected after use or as a breakdown product of codeine.
- Codeine — An opiate often prescribed for pain or cough that can be detected in blood.
- Hydrocodone / Hydromorphone — Prescription opiates that may be included in the confirmation panel.
- Oxycodone / Oxymorphone — Prescription opiates that may be included in the confirmation panel.
Who it is for
Healthcare providers order this test for patients in emergency settings, pain-management programs, or pre-surgical evaluations when there is a need to check for recent opiate use.
Preparation
No fasting or special preparation is usually required. Tell the provider about any prescription or over-the-counter medications you take, as some can affect test results.
Results and what they mean
Results are typically reported as positive or negative for the screen, with confirmation listing which specific opiates were found. A clinician interprets these results alongside your history and other findings. This information is general and not medical advice; discuss your results with a qualified healthcare professional.
How to order this test
- Choose the test and place a confidential order online.
- Select a certified collection site and pick a time that suits you.
- Have your specimen collected — most draws take only a few minutes.
- Review results in a secure portal, typically within 1–3 days.
Preparation, hours, and pricing vary by site; confirm details directly with the lab before your visit.
Availability by state
Direct-access online ordering for the opiate screen and confirmation is available in most states. It is currently unavailable in 6 states:
Everywhere else you can order confidentially and collect your sample at a certified site. Browse by state →
Frequently asked questions
How long do opiates stay in the blood?
Detection times vary by drug, dose, and individual factors, but many opiates can be detected in blood for several hours to a few days after use.
Can prescription medications cause a positive result?
Yes. Some prescription opiates and certain other medications can trigger a positive screen, which is why confirmation testing is done.
Is this test private?
Yes. Your results are confidential and protected by privacy laws; they are shared only with you and your healthcare provider.
What if the screen is positive but confirmation is negative?
That means the initial screen flagged a possible opiate, but the more precise confirmation did not find one. Your provider will interpret what this means for you.